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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Cepharanthine, Cisplatin
Phytochemical Name Cepharanthine (PubChem CID: 10206 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 15
Ref_1
Pair Name Cepharanthine, Cisplatin
Disease Info [ICD-11: 2B70] Esophageal cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Expression ABCB1 hsa5243
Up-regulation Expression APAF1 hsa317
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression CYCS hsa54205
Up-regulation Phosphorylation JUN hsa3725
Up-regulation Phosphorylation MAPK8 hsa5599
Up-regulation Cleavage PARP1 hsa142
Up-regulation Expression TP53 hsa7157
In Vitro Model Eca-109 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_6898
In Vivo Model Eca109 (3×10⁶) and Eca109/CDDP cells were injected subcutaneously (s.c.) into the flanks of mice.
Result Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
03. Reference
No. Title Href
1 Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals. Oncotarget. 2017 Nov 27;8(67):111144-111160. doi: 10.18632/oncotarget.22676. Click
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